Phase III elimination: another two-edge sword.

Phase III elimination: another two-edge sword.

Excretion into bile is well recognized as a major pathway for the elimination of amphipathic, hydrophobic, high molecular weight xenobiotics and thus complements the renal elimination of hydrophilic compounds of low molecular weight. For many xeno-biotics, excretion in bile, which has been termed a phase III elimination reaction (1), begins with an oxidation reaction (phase I), followed by conj...

The Role of Microgravity in Cancer: A Dual-edge Sword

Since human beings could travel beyond the earth atmosphere, scientists started to investigate the effect of microgravity on human cells. Microgravity has different effects on normal and cancer cells, but the related mechanisms are not well-known till now. The aim of the present review is to focus on the consequences of exposing the cancer cells to reduced gravity. Some cancer cells organize th...

The Role of Microgravity in Cancer: A Dual-edge Sword

Since human beings could travel beyond the earth atmosphere, scientists started to investigate the effect of microgravity on human cells. Microgravity has different effects on normal and cancer cells, but the related mechanisms are not well-known till now. The aim of the present review is to focus on the consequences of exposing the cancer cells to reduced gravity. Some cancer cells organize th...

The two-edged sword.

Unlike most chronic illnesses which have been declining or stabilizing in prevalence, incidence of type 2 diabetes has been increasing in the Western Hemisphere, and is now increasing at alarming rates in Asia1. While all causes of these increases cannot be identified, without question the increase in adiposity is an important contributor. The latter is due to increased caloric intake and reduc...

Class III Antiarrhythmics: put to the SWORD?